Introduction to EEK: Pioneering Excellence Since 1992
For over three decades, EEK has stood at the forefront of pharmaceutical and nutraceutical innovation. Established in 1992, we’ve grown into one of China’s largest manufacturers of hard capsules, specializing in Hypromellose (HPMC), Gelatin, and Pullulan capsules.
With a global footprint spanning temperature-controlled warehouses in the USA, Europe, Canada, and Australia, EEK delivers precision-engineered empty capsules to leading pharmaceutical and nutraceutical brands worldwide.
Today, we’re excited to introduce our latest innovation: liquid capsules, a game changer for oil-and liquid capsules.
In this comprehensive guide, we’ll explore:
- The science behind liquid-filled capsules.
- HPMC banding technology—the cornerstone of sealing liquid capsules.
- Why HPMC is the superior choice for liquid encapsulation.
Chapter 1: Liquid Capsules—The Next Frontier in Nutraceuticals
1.1 The Rise of Liquid Supplementation
The global nutraceutical industry is shifting toward liquid formulations. Oils (fish oil, CBD, vitamin E) and liquid botanicals (turmeric extracts, herbal tinctures) offer enhanced bioavailability and faster absorption. However, traditional softgels have limitations:
- Stability issues: Oxidation risks in softgels.
- Dietary restrictions: Gelatin-based softgels exclude vegan/vegetarian consumers.
- Manufacturing complexity: High heat and humidity requirements.
Enter liquid hard capsules—a hybrid solution combining the convenience of hard capsules with the efficacy of liquid payloads.
1.2 EEK’s Liquid Capsule Innovation
EEK’s liquid capsules use two-piece hard shells (size 00 to 4)filled with oils, suspensions, or emulsions. Benefits include:
- Oxidation resistance: Tight seal minimizes air exposure.
- Versatility: Compatible with HPMC, Pullulan, and gelatin shells.
- Consumer appeal: Clean-label, allergen-free options.
But the critical challenge? Preventing leaks. This is where banding technology comes in.
Chapter 2: Banding Technology Explained—Sealing the Future
2.1 What Is Banding Technology?
Banding is a mechanical or thermal process that fuses the cap and body of a hard
capsule to create an airtight seal. For liquid formulations, this seal must withstand internal pressure, temperature fluctuations, and mechanical stress during shipping.
Traditional banding methods (gelatin-based adhesives) face limitations:
- Limited compatibility with non-gelatin shells (HPMC/Pullulan).
- Risk of leaching or interaction with liquid contents.
EEK’s breakthrough: HPMC-based banding technology, specifically engineered for HPMC liquid capsules.
2.2 How HPMC Banding Works
- Precision Application: A thin band of pharmaceutical-grade HPMC solution is applied to the capsule’s join area.
- Controlled Drying: The solution dries under regulated humidity, forming a flexible yet impermeable seal.
- Quality Assurance: Capsules undergo leak tests in vacuum chambers to validate seal integrity.
Advantages of HPMC Banding:
- Material consistency: Same HPMC used in shells ensures compatibility.
- No additives: Eliminates the need for adhesives or plasticizers.
- Thermal stability: Withstands temperatures up to 50°C, ideal for global shipping.
Chapter 3: Why HPMC Is the Gold Standard for Liquid Capsules
3.1 HPMC vs. Gelatin: A Comparative Analysis
3.2 Technical Superiority of HPMC Banding
- Barrier Properties: HPMC’s low oxygen permeability (<0.5 cm³/m²/day) protects oxidation-sensitive oils like omega-3s.
- Dissolution Profile: USP-compliant disintegration in 30 minutes, ensuring rapid release.
- Regulatory Compliance: Meets FDA 21 CFR §173.55 and EU Directive 95/2/EC for food-grade polymers.
Chapter 4: EEK Proprietary Banding Process
4.1 Step-by-Step Production Workflow
- Capsule Shell Production: HPMC shells are molded to precise sizes (00 to 4).
- Liquid Filling: Oils/suspensions are dosed with rotary piston fillers (±1% accuracy).
- Sealing & Banding: Capsules are sealed and banded using a Bosch GKF 2500 machine.
- Polishing & Inspection: Vision systems check for defects; capsules are polished for shine.
- Packaging: Bottled or blister-packed with nitrogen flushing.
4.2 Quality Control & Stability Testing
- Leak Testing: Capsules undergo vacuum testing to validate seal integrity.
- Accelerated Stability: 3-month studies simulate 24-month shelf life.
- Third-Party Certifications: Eurofins, SGS, and NSF testing available.
Chapter 5: Applications of Liquid Capsules
5.1 CBD & Omega-3 Oils
- Problem: Softgels often leak or oxidize.
- Solution: HPMC banding + nitrogen flushing extends shelf life by 50%.
5.2 Probiotic Suspensions
- Problem: Powders require large capsules.
- Solution: Liquid suspensions with 10B CFU/g in smaller, easier-to-swallow capsules.
5.3 Vitamin D3 & Other Sensitive Nutrients
- Problem: Light and heat degrade actives.
- Solution: Opaque HPMC shells + banding protect against UV and humidity.
Chapter 6: Why Choose EEK for Private Label Liquid Capsules?
6.1 Low MOQs & Fast Turnaround
- MOQ: 500 units per SKU.
- Lead Time: 30 days from formulation to shipping.
6.2 Custom Formulations & Global Compliance
- Ingredients: Add vitamins, herbs, or proprietary blends.
- Certifications: FDA, EU, TGA, and Health Canada compliance.
FAQs: HPMC Banding & Liquid Capsules
Q: Can HPMC-banded capsules handle essential oils?
A: Yes! Our banding technology prevents evaporation of volatile oils like peppermint.
Q: Are HPMC capsules more expensive thangelatin?
A: Costs are comparable at scale, with added value for vegan and Halal markets.
EEK combines decades of expertise with HPMC banding technology to deliver liquid capsules that outperform softgels and traditional hard capsules. Whether you’re launching CBD, probiotics, or omega-3s, we provide the tools to dominate your niche.
Ready to Innovate?
Visit www.eekpharma.com or email kevin@eekpharma.com to request free samples or a quote!